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Faster and more effective healing of top 20% severe cases*

Increased oxygen saturation very effective in severe cases

 Increased oxygen saturation stimulates neovascularization

Significantly decreased oxygenation (p < 0.05) at peri-implantitis and periodontitis sites compared to healthy tissue

Over 30 years of clinical experience

* see literature

Wound healing requires a variety of cells to increase their metabolic activity. blue®m oxygen technology accelerates wound healing, implant integration and bone regeneration in a safe, effective and non-invasive approach. The secret is a slow release of exactly the right % active oxygen in a controlled manner directly to the treatment site. Increasing oxygen pressure is very effective for severe oral problems and the following indications:

  • Acute wound healing after implant placement or extraction
  • Gingivitis
  • Periodontitis
  • Peri-implant mucositis
  • Peri-implantitis

Active ingredients
Accelerated tissue remodeling: Sodium Perborate¹⁹
Application of blue®m (oral gel) to injured tissues accelerates wound healing. Tissue oxygenation at peri-implantitis sites was significantly decreased (p < 0.05) when compared with healthy sites¹⁸.

Plaque control: Sodium Perborate²¹ ²² Honey²⁰ ²³ and Xylitol²⁵ ²⁶
Oxygen molecules (O2 ) can penetrate much deeper into the biofilm to kill the anaerobic bacteria than the Chlorhexidine (C22H30Cl2N10) molecule. Oxygen molecules (O2 ) can penetrate much deeper into the perimucosal seal around the implant.

Antiseptic: Methyl Salicylate³⁸ ³⁹
Methyl Salicylate has an antiseptic effect and there is some thought that methyl salicylate may have an anti-inflammatory effect as well.

Bone growth accelerator: Lactoferrin²⁷ ²⁸
Lactoferrin potently stimulates the proliferation and differentiation of primary osteoblasts.

Literature
  1. Eisenbud DE. Oxygen in Wound Healing. Clin Plastic Surg 39 2012: 293-310
  2. Hopf HW, Gibson JJ, Angeles EP et al. Hyperoxia and angiogenesis. Wound Repair Regen 2005; 13:558-64
  3. Niinikoski J. Effect of oxygen supply on wound healing and formation of experimental granulation tissue. Acta Physiol Scand Suppl. 1969;334:1-72
  4. Hunt TK, Pai MP. The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg Gynecol Obstet. 1972;135(4): 561-567
  5. Hsu RW, Hsu WH, Tai CL, Lee KF. Effect of hyperbaric oxygen therapy on patellar tendinopathy in a rabbit model. J Trauma. 2004;57(5):1060-1064
  6. Hohn DC, MacKay RD, Halliday B, Hunt TK. The effect of O2 Surg Forum. 1976; 27(62):18-20
  7. Sen CK. Wound healing essentials: let there be oxygen. Wound Repair Regen 2009; 17:1-18
  8. Dalton SJ, Whiting CV, Bailey JR, Mitchell DC, Tarlton JF. Mechanism of chronic skin ulceration linking lactate, transforming growth factor-beta, vascular endothelial growth factor, collagen remodeling, collagen stability, and defective angiogenesis. J Invest Dermatol. 2007;127(4):958-968
  9. Silverstein, P. “Smoking and wound healing. Am. J. Med., 1992;93 (Suppl 1A):22S-24S.
  10. Carrico TJ, Mehrhof AI, Cohen IK. “Biology of wound healing.” Surg Clinics of North America. 1984;64(94):721-733
  11. Cruse PJE, Foord R. “A prospective study of 23,649 surgical wounds.” Arch Surg. 1973;107:2006-210
  12. Sashwati R, Savita K, Kishore N, Thomas K. Dermal wound healing is subject to redox control. Mol Ther 2006; 13: 211-220 2
  13. Fife CE, Buyukcakir C, Otto GH et al. The predictive value of transcutaneous oxygen tension measurement in diabetic lower extremity ulcers treated with hyperbaric oxygen therapy: a retrospective analysis of 1,144 patients. Wound Repair Regen 2002; 10:198-207
  14. Cho M, Hunt TK, Hussain MZ. Hydrogen peroxide stimulates macrophage vascular endothelial growth factor release. Am J Physiol Heart Circ Physiol 2001; 280: H2357–H2363
  15. Saissy JM, Guignard B, Pats B et al. Pulmonary edema after hydrogen peroxide irrigation of a war wound Intens Care Med 1995; 21:287-288
  16. Pruitt KM, Reiter B. Biochemistry of peroxidase system: antimicrobial effects in the lactoperoxidase system. New York 1985: 143
  17. Hyslop PA, Hinshaw DB, Scraufstatter IU et al. Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defence. Free radical Biology and Medicin 1995; 19:31-7
  18. Nogueira-Filho G, Xiang XM, Shibli JA, Duarte PM, Sowa MG, Ferrari DS, Onuma T, de Cardoso LA, Liu KZ. On site noninvasive assessment of peri-implant inflammation by optical spectroscopy. J Periodontal Res. 2011 Jun;46(3):382-8
  19. SAENZ de PIPAON y TEJADA M. Nascent oxygen from sodium perborate in oral disinfection and hygiene Odontoiatr Rev Iberoam Med Boca. 1950;7(83):617-50
  20. Majtan J. Honey: An immunomodulator in wound healing Wound Rep Reg 2014 22 187–192
  21. Fernandez y Mostajo M, van der Reijden WA, Buijs MJ, Beertsen W, Van der Weijden F, Crielaard W, Zaura E. Effect of an oxygenating agent on oral bacteria in vitro and on dental plaque composition in healthy young adults Frontiers in Cellular and Infection Microbiology July 2014, Volume 4
  22. Ntrouka V, Hoogenkamp M, Zaura E, van der Weijden F. The effect of chemotherapeutic agents on titanium-adherent biofilms. Clin. Oral Implants 2011 Res. 22, 1227–1234
  23. Aparna S, Srirangarajan S, Malgi V, Setlur KP, Shashidhar R, Setty S, Thakur S. Effect of honey in preventing gingivitis and dental caries in patients undergoing orthodontic treatment The Saudi Dental Journal 2014 26, 108–114
  24. A Comparative Evaluation of the Antibacterial Efficacy of Honey In Vitro and Antiplaque Efficacy Preliminary Results J Periodontol September 2012
  25. Badet C, Furiga A, Thébaud N. Xylitol inhibits inflammatory cytokine expression induced by lipopolysaccharide from Porphyromonas gingivalis. Clin Diagn Lab Immunol. 2005 Nov; 12(11):1285-91
  26. Effect of xylitol on an in vitro model of oral biofilm. Oral Health Prev Dent. 2008;6(4):337-41
  27. Naot D et al. Lactoferrin – A Novel Bone Growth Factor Clin Med Res. 2005 May; 3(2): 93–101
  28. J Cornish. Lactoferrin promotes bone growth. Biometals. 2004 Jun;17(3):331-5
  29. Ingrid Milošev, Barbara Kapun, Vid Simon Šelih. The effect of fluoride ions on the corrosion behaviour of Ti metal, and Ti6-Al-7Nb and Ti-6Al-4V alloys in artificial saliva. Acta Chim Slov. 2013;60(3):543-55
  30. Nakagawa M1, Matsuya S, Shiraishi T, Ohta M. Effect of Fluoride Concentration and pH on Corrosion Behavior of Titanium for Dental Use. J DENT RES 1999 78: 1568
  31. Juliana Noguti, Flavia de Oliveira, Rogério Correa Peres, Ana Claudia Muniz Renno, Daniel Araki Ribeiro. The role of fluoride on the process of titanium corrosion in oral cavity. Biometals (2012) 25:859–86234
  32. Geetha Manivasagam, Durgalakshmi Dhinasekaran and Asokamani Rajamanickam. Biomedical Implants: Corrosion and its Prevention – A Review Recent Patents on Corrosion Science, 2010, 2, 40-54
  33. Vicentini BC, Braga SR, Sobral MA. The measurement in vitro of dentine abrasion by toothpastes. Int Dent J. 2007 Oct;57(5):314-8
  34. Berendsen JLM, el Allati I, Sylva LH, Blijdorp PA, Meijer GJ. Adjunctive topical Reactive Oxygen Species (ROS) in periodontitis and peri-implantitis – a pilot study 2008
  35. Makeeva IM, Tambovtseva NV. Application of toothpaste and mouthwash “BlueM” in complex hygienic oral care for patients with coronary heart disease. Stomatologiia (Mosk). 2014;93(3):18-20
  36. Makeeva IM, Tambovtseva NV. Optimization of hygienic oral care in patients with dental implants based on use of toothpaste and mouthwash: a pilot study. 2014
  37. Makeeva IM, Tambovtseva NV. Use of oral hygiene products containing active oxygen in patients with pemphigus vulgaris: a pilot study. 2014
  38. Erriu M et al. Oil Essential Mouthwashes Antibacterial Activity against Aggregatibacter actinomycetemcomitans: A Comparison between Antibiofilm and Antiplanktonic Effects. Int J Dent. 2013;2013:164267. doi: 10.1155/2013/164267. Epub 2013 May 18
  39. Mason L et al. Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain”. BMJ 328 (7446): 995
  40. Dr. Céline M. Lévesque. In vitro evaluation of antimicrobial activity of BlueM mouthwash: a pilot study. January 24, 2018

blue®m Research and cases

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Do you want to use blue®m in your practice?

Many dental specialists already preceded you, blue®m is used and advised in more than 45 countries. To start with blue®m, you do not need much other than a few tubes of oral gel and a brief instruction about the use. You can go through the directives , but we could also explain it to you and your team in person.

In addition to lectures and presentations we organise and we teach study groups as well. We are happy to answer all your questions about the use of our products in practice. If you have questions let us know!

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